In this scenario, the student is expected to counsel a pataient who is about to start methotrexate for their condition. Their role is to answer the patient’s questions appropriately and provide them with any important information.
Please ensure that this scenario and mark scheme aligns with the most up-to-date guidelines from the UK NICE and the BNF when using it for your OSCE assessment.
You will need a student pharmacist and an actor for this OSCE station.
Methotrexate
Rheumatoid Arthritis
You are the pharmacist. You have been asked to counsel a patient who has recently been initiated on methotrexate for rheumatoid arthritis. The patient is a 47-year-old female who has recently been diagnosed with rheumatoid arthritis and has been prescribed methotrexate weekly injections.
To do
Provide the patient with detailed information about their medication, addressing any questions, concerns and queries they may have regarding their treatment plan and condition.
You have 10 minutes.
You have access to the BNF.
You are Ayna Hertford (Eye-na, Hurt-ford).
Opening statement: "I've just been prescribed methotrexate injections for my rheumatoid arthritis, and I have some questions about it."
Patient information:
Provide this information when prompted.
Name: Ayna Hertford
Age: 47
Prescription:
Methotrexate 7.5 mg once weekly via subcutaneous injection
Past medical history:
Rheumatoid arthritis (recently diagnosed)
High blood pressure
Medication History:
Lisinopril 10 mg once daily for high blood pressure
Ibuprofen 400 mg as needed for pain
Allergies:
“None”
Symptoms:
"I have joint pain and swelling, particularly in my hands and knees."
"I experience morning stiffness that lasts more than 30 minutes."
"The doctor said the blood tests showed 'inflammation.'"
"I'm a non-smoker."
"I drink alcohol socially, about 1-2 glasses of wine per week."
"I work as a teacher."
"I live with my husband and two teenage children."
"I have a moderate exercise routine that includes walking and yoga."
"I'm postmenopausal."
You have not started taking the medication yet. You do not know much about methotrexate other than it is for your rheumatoid arthritis, so you wanted to clarify some questions first.
Questions:
If the student does not know – ask them if there is someone that would know.
Any criteria marked in red must be met to pass this station.
Referral Criteria for Methotrexate
Refer to Accident and Emergency (A&E) if:
Lips or tongue become swollen, difficulty breathing or struggling to swallow: Signs of allergic reaction.
Refer for an Urgent GP Appointment if:
Oral ulcers present: Sign of bone marrow suppression, increasing likelihood of infection.
sore throat: Sign of bone marrow suppression, increasing likelihood of infection.
Unexplained rash: This could indicate a severe allergic reaction or drug-induced skin conditions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis.
abnormal bruising: could be a sign of thrombocytopenia (a low platelet count) or bone marrow suppression.
Persistent diarrhoea: a sign of gastrointestinal toxicity, which could lead to severe dehydration and electrolyte imbalances.
Yellowing of skin or eyes, abdominal pain: May indicate liver toxicity.
Swollen hands or feet, and difficulty urinating: May indicate renal impairment.
Bleeding in gums, urine, vomit, bruising: Possible indicator for agranulocytosis.
New or increasing dyspnoea or dry cough: may indicate methotrexate-induced pneumonitis, a potentially serious lung condition.
HSC Public Health Agency. (n.d.).Methotrexate Oral (Adult) Shared Care Guidelines. [PDF] Available at:https://ipnsm.hscni.net/download/19/shared-care-guidelines/1432/methotrexate-oral-adult.pdf[Accessed 20 Aug. 2024].
National Health Service (NHS). (2023).Methotrexate. [online] Available at:https://www.nhs.uk/medicines/methotrexate[Accessed 20 Aug. 2024].
National Institute for Health and Care Excellence (NICE). (2023).Methotrexate: BNF. [online] Available at:https://bnf.nice.org.uk/drugs/methotrexate/[Accessed 20 Aug. 2024].
Electronic Medicines Compendium (EMC). (2023).Methotrexate 2.5mg Tablets - Summary of Product Characteristics (SmPC). [online] Available at: https://www.medicines.org.uk/emc/product/511/smpc#gref
National Rheumatoid Arthritis Society (NRAS) (n.d.) Possible causes and risk factors. Available at: https://nras.org.uk/resource/possible-causes-and-risk-factors/ (Accessed: 12 January 2025).
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